- Echeneidae Rafinesque 1810
- Echinasteridae Verrill 1870
- Echinolampadidae Gray 1851
- Echinometridae Gray 1855
- Echinorhynchidae Cobbold 1879
- Echinostomatidae Looss 1899
- Echinothuriidae Thomson 1872
- Eimeriidae Minchin 1903
- Eirenidae Haeckel 1879
- Elaeagnaceae de Jussieu 1789
- Elaeocarpaceae de Jussieu 1816
- Elateridae Leach 1815
- Eleotridae Bonaparte 1835
- Elephantidae Gray 1821
- Ellisellidae Gray 1859
- Ellobiidae L. Pfeiffer 1854 (1822)
- Elmidae Curtis 1830
- Emberizidae Vigors 1831
- Embiotocidae Agassiz 1853
- Emmelichthyidae D.S. Jordan 1923
- Emydidae Rafinesque 1815
- Endocladiaceae (J. Agardh) Kylin 1928
- Engraulidae Gill 1861
- Enidae B.B. Woodward 1903 (1880)
- Enterobacteriaceae Rahn 1937
- Ephemeridae Leach 1817
- Ephippidae Bleeker 1859
- Epilampridae Brunner von Wattenwyl 1865
- Epiphanidae Harring 1913
- Epitoniidae Berry 1910 (1812)
- Epizoanthidae Delage & Hérouard 1901
- Equisetaceae Michaux ex de Candolle 1804
- Ergasilidae Burmeister 1835
- Ericaceae de Jussieu 1789
- Erinaceidae G. Fischer 1814
- Eriphiidae MacLeay 1838
- Erotylidae Latreille 1802
- Esocidae G. Cuvier 1817
- Esperiopsidae Hentschel 1923
- Estrildidae Illiger 1811
- Eucalanidae Giesbrecht 1893
- Euchlanidae Ehrenberg 1838
- Eucoilidae Thomson 1862
- Euconulidae Baker 1928
- Eudendriidae L. Agassiz 1862
- Euglenaceae
- Eulimidae Philippi 1853
- Eumenidae
- Eunicidae Savigny 1818
- Euphausiidae Dana 1852
- Euphorbiaceae de Jussieu 1789
- Euphylliidae Alloiteau 1952
- Euplectellidae Gray 1867
- Eurhamphaeidae L. Agassiz 1860
- Eurytheneidae Stoddart & Lowry 2004
- Eurytomidae Walker 1832
- Exocoetidae Risso 1827